![]() ![]() Suffice it to say that vitamin K2 helps to unlock the full potential of the “sunshine vitamin.” Forgotten vitamin, big potential However, not everyone is aware of the important role that vitamin K (particularly K2) plays in vitamin D function. Conclusions: The combination of vitamin K and D can significantly increase the total BMD and significantly decrease undercarboxylated osteocalcin, and a more favorable effect is expected when vitamin K 2 is used.Many people have become familiar with vitamin D’s potential impact on optimal immunity and bone health. Simultaneously, subgroup analysis showed that K 2 or vitamin K (not specified) supplement was less than 500 μg d −1, which when combined with vitamin D can significantly increase the total BMD compared with the control group fed a normal diet or the group with no treatment (0.479, 0.101 to 0.858 and 0.570, 0.196 to 0.945). A significant decrease in undercarboxylated osteocalcin (−0.945, −1.113 to −0.778) can be observed with the combination of vitamin K and D. ![]() Vitamin K combined with vitamin D significantly increased the total bone mineral density (BMD): the pooled effect size was 0.316. Method and findings: A comprehensive search on Web of Science, PubMed, Embase and the Cochrane Library (from 1950 to February 2020) and bibliographies of relevant articles was undertaken, with the meta-analysis of eight randomized controlled trials (RCTs) including a total of 971 subjects. Background: Previous studies did not draw a consistent conclusion about the effects of vitamin K combined with vitamin D on human skeletal quality.
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